Alternate Continuity: Ghosts is explicitly independent from both of the previous non-historical Call of Duty timelines, Modern Warfare and Black Ops.At the start of the game the United States and the Federation are in an uneasy peace, until the Federation decides it wants to add America to its empire. The Federation would quickly expand until it controlled all of South America, Central America, and the Caribbean. This event gave the oil-rich nations of South America a virtual monopoly on oil, allowing them to form the Federation of the Americas. Alternate History: The game takes place in an alternate 21st century where a devastating conflict in the Middle East greatly depleted the world's oil supply and resulted in a global energy crisis.Alien Invasion: Due to the popularity of the 'Zombies' gameplay mode in the Treyarch-made Call of Duty games, Infinity Ward has included a new multiplayer mode in Ghosts titled 'Extinction' where teams of players must defend an area against waves of attacking aliens.

After the End: The game takes place in an America with its power shattered by ROG strikes.special forces are brought together to become the 'Ghosts', whose mission is to use whatever means necessary to defend the tattered remains of the U.S. After ten years of occupation by The Federation, what remains of the U.S. This results in a weakened military and exposure to invasion, which comes in the form of a collective of South American governments called 'The Federation' (the ones who were also responsible for bringing this on the U.S. The severe loss of industry, infrastructure, and capital to rebuild has taken the government from one of the most elite nations in the world to third-world status. Ten years in the aftermath of an attack caused by turning a United States satellite weapon against the nation, much of the country lays in ruins. However, his talent and Hollywood success did not extend to the first-person shooter realm, and the Ghosts brand and storyline was retired after this one installment due to lackluster sales and criticism of its plot and villains. The tenth game in the popular FPS series Call of Duty, developed by Infinity Ward, Ghosts was intended to be the start of an entirely new subseries for the franchise by acclaimed writer/director Stephen Gaghan.

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